Farnesyl pyrophosphate is a new danger signal inducing acute cell death
نویسندگان
چکیده
منابع مشابه
Asthma is a Serious Danger
میزان مرگ و میر آسم طی دهه گذشته بطور چشمگیری تغییر کرده است. با مبتلا کردن ۱۵ میلیون آمریکایی میزان مرگ و میر در سال ۱۹۷۸، به رقم ۱۸۷۲ نفر و ۹ سال بعد، به بیش از ۴۰۰۰ نفر رسید. علت چنین افزایش چشمگیری روشن نیست. علل احتمالی عبارتند از کاهش ظرفیت تنفس، استفاده بیش از حد از داروهای استثنائی و استنباط غلط بیماران و نیز مراکز درمانی نسبت به شدت بیماری است. بررسی دقیق، معالجات مناسب و آموزش به ب...
متن کاملBiosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene.
The intermediate, discovered by Rilling, between farnesyl pyrophosphate and squalene was synthesized in milligram quantities with yeast subcellular particles from farnesylJ4Cpyrophosphate and from farnesyl-l-3H&4C-pyrophosphate. The 3H : l4C ratio in the new squalene precursor was found to be identical with that in the farnesyl pyrophosphate, whereas the ratio in squalene was close to the expec...
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Temperature-sensitive transient receptor potential ion channels (thermoTRPs) expressed in epidermal keratinocytes and sensory afferents play an important role as peripheral pain detectors for our body. Many natural and synthetic compounds have been found to act on the thermoTRPs leading to altered nociception, but little is known about endogenous painful molecules activating TRPV3. Here, we sho...
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Background Glioblastoma is the most common primary malignant brain tumor, and despite multimodal treatment with surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, the prognosis is poor, with a median survival of 16 to 19 months [1]. Therefore, alternative treatments are necessary. A therapy anticipated to be one of the most effective anticancer treatments is tumor necrosis factor-relat...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2021
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.3001134